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. 2018 Sep 7;19(9):2661. doi: 10.3390/ijms19092661

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AWRK6 relieved lipopolysaccharide (LPS)-induced liver injury in mice. The mice were administrated with LPS (50 mg/kg) by intraperitoneal injection. AWRK6 (10 mg/kg) or PMB (10 mg/kg) was administered intraperitoneally 1 h after LPS and an equal volume of sterile saline was used as a negative control. (A) The protective effect of AWRK6 on enhanced ALT activity in LPS-treated mice liver, assayed by Alanine aminotransferase Assay Kit. (B) The effect of AWRK6 on SOD activity in LPS-treated mice liver assayed by Superoxide Dismutase Assay Kit. (C) The effect of AWRK6 on iNOS activity in LPS-treated mice liver, assayed by Nitric Oxide Synthase Assay Kit. (D) Histologic changes of liver tissues upon LPS and AWRK6 treatment, stained with HE. (E) Micrographs of liver sections stained with MPO antibody. (F) The analysis of liver sections stained with MPO was carried out using ImageJ. * p < 0.05 compared with the LPS groups. Scale bar indicates 100 μm.

AWRK6 relieved lipopolysaccharide (LPS)-induced liver injury in mice. The mice were administrated with LPS (50 mg/kg) by intraperitoneal injection. AWRK6 (10 mg/kg) or PMB (10 mg/kg) was administered intraperitoneally 1 h after LPS and an equal volume of sterile saline was used as a negative control. (A) The protective effect of AWRK6 on enhanced ALT activity in LPS-treated mice liver, assayed by Alanine aminotransferase Assay Kit. (B) The effect of AWRK6 on SOD activity in LPS-treated mice liver assayed by Superoxide Dismutase Assay Kit. (C) The effect of AWRK6 on iNOS activity in LPS-treated mice liver, assayed by Nitric Oxide Synthase Assay Kit. (D) Histologic changes of liver tissues upon LPS and AWRK6 treatment, stained with HE. (E) Micrographs of liver sections stained with MPO antibody. (F) The analysis of liver sections stained with MPO was carried out using ImageJ. * p < 0.05 compared with the LPS groups. Scale bar indicates 100 μm.