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Comparison of mutant and wild-type GDH enzyme kinetics in 293T cells.
| 293T cells | GTP IC50 (nM) |
|---|---|
| Wild type | 80 |
| p.R221C | 600 |
| p.H262Y | 450 |
| p.R269H | 1060 |
| p.N410S | 53500 |
| p.N410I | 31060 |
| p.R443W | 63200 |
| p.S445L | 45100 |
| p.G446C | 48400 |
| p.V453M | 158000 |
| p.H454Y | 298000 |
