Table 3.

Hierarchical regression models demonstrating the associations between hyperemic velocity change and neurocognition. Values represent standardized regression coefficients. HRSD = Hamilton Rating Scale for

Predictor	Model 1	Model 2	Model 3
Working Memory
Age	------	−0.30**	−0.28**
Education	------	0.41**	0.33**
Gender	------	−0.01	0.01
HRSD	------	0.11†	0.09
HDL	------	------	0.05
LDL	------	------	0.03
Framingham Stroke Risk	------	------	−0.18*
Base Velocity	0.19*	0.17*	0.14†
Hyperemic Velocity %	0.25**	0.15†	0.06
Executive Function
Age	------	−0.44**	−0.43**
Education	------	0.30**	0.23**
Gender	------	−0.09	−0.05
HRSD	------	0.05	0.03
HDL	------	------	0.09
LDL	------	------	0.08
Framingham Stroke Risk	------	------	−0.16*
Base Velocity	0.22**	0.17*	0.14†
Hyperemic Velocity %	0.28**	0.11	0.03
Verbal Memory
Age	------	0.00	0.06
Education	------	0.23**	0.20**
Gender	------	−0.03	−0.04
HRSD	------	−0.01	−0.01
HDL	------	------	−0.08
LDL	------	------	−0.03
Framingham Stroke Risk	------	------	0.08
Base Velocity	−0.05	−0.06	−0.04
Hyperemic Velocity %	0.15†	0.15†	0.21*

Depression; HDL = high density lipoprotein; LDL = low density lipoprotein.

^†P<.10

^*P<.05

^**P<.01