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. Author manuscript; available in PMC: 2019 Sep 30.
Published in final edited form as: J Leukoc Biol. 2018 Mar 30:10.1002/JLB.3CE0118-032R. doi: 10.1002/JLB.3CE0118-032R

Figure 1. Transcellular metabolism and actions of RvD4.

Figure 1

In endothelial cells, docosahexaenoic acid (DHA) is metabolized to 17(S)-hydroxydocosahexaenoic acid (HDHA) by 15-Lipoxygenase (15-LOX). 17(S)-HDHA undergoes transcellular trafficking to adjacent neutrophils where 5-lipoxygenase (5-LOX) can generate RvD4. RvD4 signals through an unknown, Gs-linked, G-Protein Coupled Receptor to promote bacterial phagocytosis by macrophages and neutrophils, and attenuate production of pro-inflammatory eicosanoids (LTB4, TXB2, PGE2 and PGF2α) by macrophages. RvD4 can be transported into cytosol of cells where it is metabolized by eicosanoid oxidoreductase (EOR) to less biologically active 17-oxo-RvD4.