Skip to main content
. Author manuscript; available in PMC: 2019 Sep 30.
Published in final edited form as: Hepatology. 2018 Jun 1;68(3):1042–1056. doi: 10.1002/hep.29898

Figure 6.

Figure 6

Tumor growth and proliferation evaluation in nu/nu mice. Tumor growth was measured in nu/nu mice treated with NaCl, the H1HR or the H2HR antagonist following tumor establishment (A). Tumors were measured every other day for 31 days. Growth of tumors significantly increased in nu/nu mice treated with saline beginning at day 13 and continued throughout the experiment (A). Nu/nu mice treated with either H1HR or H2HR antagonists had blunted tumor growth throughout the treatments compared to NaCl-treated mice (A). PCNA gene expression decreased in tumors from nu/nu mice treated with either H1HR or H2HR antagonists compared to saline treatment (B) and Ki-67 staining was reduced in tumors from nu/nu mice treated with H1HR or H2HR antagonists compared to saline treatment (C). Data are mean ± SEM of 6 experiments for real-time PCR. *p<0.05 versus saline treatment. Representative images are 20X magnification.