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. Author manuscript; available in PMC: 2019 Sep 30.
Published in final edited form as: J Leukoc Biol. 2018 Mar 30:10.1002/JLB.3MIR0817-338R. doi: 10.1002/JLB.3MIR0817-338R

Figure 3. Activated protein C (APC) and leukocyte inflammation.

Figure 3

Inflammatory signaling by leukocytes is driven in part via protein kinase C (PKC) signaling to generate reactive oxygen species (ROS) through NADPH oxidase, resulting in development of an activated inflammasome and/or formation of NETs. APC inhibits leukocyte inflammatory processes in a receptor-dependent manner, requiring Mac-1 (CD11b/CD18), endothelial protein C receptor (EPCR), PAR1 and PAR3, inducing intracellular cytoprotective signaling. Figure adapted from [69].