. Author manuscript; available in PMC: 2019 Sep 30.

Published in final edited form as: J Leukoc Biol. 2018 Mar 30:10.1002/JLB.3MIR0817-338R. doi: 10.1002/JLB.3MIR0817-338R

TABLE 1.

Innate immune cells regulated by APC.

Cell type	Cell line	Receptors	Inhibitory effects	References
Monocytes	Primary [Human] (blood)	Unknown	Reduction in MIP-1-α release in septic patients and healthy volunteers	[65,66]
			Reduction in expression of CD14, CD11b and CD18 induced by INF-γ or PMA

	THP-1 U937	EPCR, PAR1, ApoER2	Reduction in MIP-1-α, MCP-1, TNF-α release ± LPS	[62,65,67]
			CAM-induced apoptosis
			Dab1-dependent signaling

Macrophages	Primary (alveolar)	Unknown	Reduction in TNF-α release in response to LPS	[66,68]
	[Mouse] (BMDM)	PAR 1	Suppression of NLRP3 inflammasome activation

Neutrophils	Primary (blood)	EPCR, integrins, PAR3	Reduction in chemotaxis	[58,60,69–72]
Neutrophils	Primary (blood)	EPCR, integrins, PAR3	No effect on spontaneous apoptosis	[58,60,69–72]
			APC cleavage of extracellular histones (in vitro and in vivo)
			Inhibition of NET s formation

Footnote. Table Abbreviations. APC: Activated protein C; BMDM: bone marrow-derived macrophages; THP-1: monocytic cell line; U937: monocytic cell line; EPCR: endothelial protein C receptor; PARs-1,3: protease activated receptor-1/3; NLRP3: NOD-like receptor 3; ApoER2: Apolipoprotein E receptor 2; MIP-1-α: macrophage inhibitory protein 1-α; INF-γ: Interferon-γ; PMA: phorbol 12-myristate 13-acetate; MCP-1: monocyte chemoattractant protein-1; TNF-α: tumor necrosis factor-α; LPS: lipopolysaccharide; CAM: camptothecin.