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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Semin Cell Dev Biol. 2018 Mar 30;86:102–111. doi: 10.1016/j.semcdb.2018.03.017

Figure 3. Models of IDL and TIP mediated cooperativity in EcSSB.

Figure 3

A) Cooperative binding of SSB tetramers in the (SSB)35 mode is shown. Proposed interactions between the IDLs of neighboring tetramers along with TIP interactions with free ssDNA binding regions in the OB-domains are denoted. B) Similar cooperative binding to ssDNA in the (SSB)65 and (SSB)56 modes are proposed to be facilitated through interactions between IDLs of multiple tetramers.