Table 1.

Cross-validation outcome of 3 trials for each condition predicted by linear discriminant analysis. The outcome of two discriminant analyses was used for the predictions. The LTD (or no LTD) discriminant analysis used spine PKC and dendritic pCamKII at 1 min, and dendritic 2AG at 3 min. The LTP (or no LTP) discriminant analysis used dendritic 2AG, spine Epac1, dendritic pCamKII, and spine pCamKII at 1 min; spine PKC and dendritic pCamKII at 2 min, and phosphorylated PKA targets in the spine at 3 min. Experimental Outcome gives the reported EPSP or population spike (PopSpike) amplitude from the publication in Source. NP indicates no plasticity determined as non-significant difference to the experimental control.

Condition	LTD	LTP	No Plasticity	Experimental Outcome	Source
20Hz, block PKA	3	0	0	LTD	(Lerner and Kreitzer 2012)*
20Hz, Control moderate Da	3	0	0	LTD (80%,86%)	(Hawes et al 2013)
20Hz, Control low Da	3	0	0	LTD (80%,86%)	(Hawes et al 2013)
TBS, Block m1	0	0	3	NP (85%)	(Hawes et al 2013)
TBS, block mGlu	0	0	3	NP (85%)	(Hawes et al 2013)
TBS, block PKA	0	0	3	NP (105%)	(Hawes et al 2013)
TBS, block DaD1R	0	0	3	NP (97%)	(Hawes et al 2013)
TBS, Control	0	3	0	LTP (135%)	(Hawes et al 2013)
STDP, ISI=−30ms	3	0	0	LTD (84%)	(Fino et al 2010)
STDP, ISI=10ms	0	3	0	LTD (176%)	(Fino et al 2010)

^*This condition is extrapolated from 100 Hz and the effect of A2A agonist at 20 Hz, both experiments performed in D2R neurons.