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. 2018 Sep 25;11:1999–2009. doi: 10.2147/JPR.S168715

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© 2018 Liang et al. This work is published and licensed by Dove Medical Press Limited

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Relationship of neuroangiogenesis with PNI.

Notes: (A) Double immunofluorescence was performed to present microvessel and newly formed nerve fibers simultaneously. Microvessels were red-stained (CD31 marked) and newly formed nerve fibers were green-stained (GAP-43 marked). The merged images showed a close nerve–vessel network in the endometriotic lesion. Further correlation analysis revealed that MVD in endometriotic lesions of the PNI (+) group was positively related to the NFD of newly formed nerve fibers; (B) USL-DIE, P<0.001; (C) RVS-DIE, P<0.001.

Abbreviations: PNI, perineural invasion; MVD, microvessel density; NFD, nerve fiber density; USL-DIE, endometriosis infiltrating the uterosacral ligament; RVS-DIE, endometriosis involving the rectovaginal septum.