Table S1.
Mean and range of cytokine level (pg/dL) at baseline visit
| Cytokine | Control
|
PDT
|
AF
|
|||
|---|---|---|---|---|---|---|
| Mean (min, max) | SD | Mean (min, max) | SD | Mean (min, max) | SD | |
| PLGF | 2.5 (0.2, 10.6) | 3.1 | 3.6 (0.1, 15.6) | 5.7 | 1.7 (0.1, 4.0) | 1.4 |
| VEGF-A | 78 (3.5, 664.8) | 184 | 177.9 (1.7, 744.2) | 269.6 | 86.8 (1.5, 386.3) | 135.2 |
| VEGF-C | 66 (6.2, 233.6) | 66.1 | 78.7 (0.9, 289.1) | 101.8 | 84.5 (4.7, 236.6) | 67.7 |
| Angiopoeitin-2 | 344 (43.3, 996.2) | 239.2 | 195.1 (11.1, 338.6) | 98.5 | 289.2 (158.6, 517.1) | 117.3 |
| EGF | 2.6 (0.6, 9.2) | 2.1 | 2.8 (0.3, 5.7) | 2.4 | 3.9 (0.3, 10.4) | 3.4 |
| Endothelin-1 | 20.3 (3.1, 36.7) | 12.9 | 9.2 (0.1, 27.2) | 11.0 | 18.2 (0.4, 43) | 15.8 |
| FGF-1 | 7.4 (1.4, 13.4) | 3.9 | 5.8 (1.5, 11) | 3.1 | 6.7 (1, 12.4) | 4.5 |
| FGF-2 | 42.6 (5.7, 112.3) | 35.5 | 32.4 (1.7, 59.8) | 24.3 | 37.7 (3.3, 98.3) | 34.4 |
| Follistatin | 72.2 (7.7, 170.9) | 60.5 | 74.3 (2.3, 206.2) | 68.2 | 199.6 (2, 1,413.9) | 407.6 |
| G-CSF | 79.2 (5.5, 210.8) | 75.4 | 150.8 (4.7, 669.1) | 226.9 | 53 (4.2, 152.7) | 45.3 |
| HBEGF | 2.4 (0.2, 0.6) | 3.3 | 3.6 (0.1, 9.9) | 3.5 | 3.1 (0.1, 7.1) | 3 |
| HGF | 1,909.9 (228.4, 2,353.1) | 743.6 | 1,729.2 (183.5, 3,750.8) | 1,022 | 2,044.2 (1,292.8, 3,314.6) | 655.6 |
| Leptin | 528.6 (16.8, 4,579.4) | 1,248.3 | 1,479.8 (14.3, 8,325.2) | 2,836.5 | 338.1 (10.2, 2,009.8) | 568.2 |
| ICAM | 2,047.2 (138.2, 12,424.8) | 3,609.6 | 5,324.1 (69, 19,380.5) | 7,024.4 | 12,928.5 (76, 115,354.1) | 36,037.2 |
| IL-1A | 8.5 (1.6, 16.3) | 4.2 | 5.4 (0.1, 11.1) | 4.2 | 7.6 (0.9, 17.4) | 5.7 |
| IL-3 | 43 (25.8, 66.9) | 11.8 | 38.4 (9, 76.3) | 24.5 | 34.3 (14.2, 77.2) | 21.1 |
| IL-6 | 81.9 (1.1, 423.0) | 140 | 458.6 (9.4, 1,186.5) | 535 | 104.4 (0.5, 487.8) | 169.0 |
| IL-7 | 1.4 (0.3, 3.2) | 1.0 | 0.8 (0.1, 2.5) | 0.9 | 0.6 (0, 2.5) | 0.7 |
| IL-8 | 13.1 (1.5, 34.8) | 9.9 | 13 (1.7, 43) | 14.1 | 8.9 (0.3, 17.9) | 5.5 |
| IL12p70 | 1.3 (0.2, 3) | 1.0 | 1.1 (0.2, 2.4) | 0.8 | 1.2 (0.2, 2.7) | 1.0 |
| IL-17 | 0.7 (0.2, 1.9) | 0.5 | 1.0 (0.2, 2.6) | 0.9 | 0.8 (0, 1.7) | 0.6 |
| MCP-1 | 3,765 (1,554, 8,231.8) | 2,145.5 | 4,914.1 (1,548, 9,421.6) | 3,426.8 | 3,751.5 (1,740.6, 7,815.3) | 2,082.7 |
| TNF-α | 0.6 (0.1, 1.3) | 0.4 | 0.5 (0.2, 1.5) | 0.4 | 0.5 (0, 1.3) | 0.4 |
| PDGF-AA | 36.3 (10, 80.5) | 19.5 | 53 (13.9, 115.3) | 38.9 | 39.3 (14.5, 67.4) | 19.7 |
Abbreviations: AF, aflibercept; EGF, epidermal growth factor; FGF, fibroblast growth factor; G-CSF, granulocyte-colony stimulating factor; HBEGF, heparin-binding EGF-like growth factor; HGF, hepatocyte growth factor; ICAM, intercellular adhesion molecule; IL, interleukin; MCP, monocyte chemoattractant protein; PDGF, platelet-derived growth factor; PDT, photodynamic therapy; PLGF, placental growth factor; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.