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. 2018 Jun 14;103(10):1627–1634. doi: 10.3324/haematol.2018.193128

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Figure 1. — RUNX1S291fs induced mice model can phenotypically recapitulate human myelodysplastic syndrome. (A) Experimental scheme of our model mouse using RUNX1S291fs mutant. (B) Chimerism of GFP⁺ cells post transplantation. (C) Successful expression of RUNX1S291fs protein detected by western blotting. (D) White blood cell (WBC) count. (E) Hemoglobin (HG) count. (F) Platelet (PLT) count. (G) Mean corpuscular volume (MCV). (H) The morphological abnormality observed in the bone marrow and spleen size. (I) Pathological changes in the femur, liver and spleen. *P<0.05, **P<0.01, ***P<0.001.