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. 2018 Jun 14;103(10):1627–1634. doi: 10.3324/haematol.2018.193128

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Figure 3. — Iron overload impairs the frequency of normal hematopoietic stem and progenitor cells (HSPCs) and affects erythroid maturation in myelodysplastic syndrome (MDS) mice. (A) Gating hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) by flow cytometry. (B) The frequency of HSCs in different groups. (C) Frequency of HPCs in different groups. (D) Different stages of erythroid through CD71 and Ter119 gating. (E) Effect of iron overload on erythroid differentiation. *P<0.05, **P<0.01. BMMNCs: bone marrow mononuclear cells; GFP-: normal; GFP+: mutant; LSK: Lin⁻c-Kit⁺Sca1⁺, HSCs; LK: Lin⁻c-Kit⁺Sca1⁻, HPCs; E1: proerythroblasts; E2: basophilic erythroblasts; E3: polychromatophilic erythroblasts; E4: orthochromatic erythroblasts.