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. 2018 Sep 28;38(5):BSR20180772. doi: 10.1042/BSR20180772

Table 2. Clinical significance of LncRNAs in BC metastasis.

LncRNA Expression Clinical significance Reference
MEG3 Down Down-regulated MEG3 was significantly associated with TNM stage and LNM in BC patients. [20]
OR3A4 Up The expression level of OR3A4 was found to be associated with LNM, differentiation grade, HER-2/neu status, and TNM stage. [23]
H19 Up Plasma levels of lncRNA H19 were significantly correlated with LNM. [87]
TUG1 Down Low TUG1 expression was significantly correlated with LNM. [88]
FGF14-AS2 Down Down-regulation of lncRNA FGF14-AS2 was correlated with more lymph node metastasis. [89]
AC010729.1 Increased expressions of AC010729.1 and RP11-482H16.1 had a shorter MFS compared with patients with low expressions of AC010729.1 and RP11-482H16.1. [90]
RP11-482H16.1
AC010729.1
RP11-482H16.1
MALAT1 Up Up-regulated MALAT1 was related to LNM. [91]
HOTAIR Up HOTAIR increased in the metastatic carcinomas and its expression in BC was a predictor of poor survival. [92]
Z38 Up High level of Z38 was significantly related to advanced TNM stage and LNM. [93]
LINC01296 Up Increased LINC01296 was positive correlated with larger tumor size, positive LNM, and advanced TNM stage of patients with BC. [94]
p10247 Up The up-regulated expression of p10247 was significantly associated with progression of clinical stage and LNM. [95]