Table 1.
Polypeptides identified in exosomes derivate from Mesenchymal Stem Cells (MSC).
| Protein name | Gene | UniProtKBa Acc. No. | MWb (kDa) | pIC |
|---|---|---|---|---|
| 1. C-C motif chemokine 2 (CCL2) | CCL2 | P13500 | 11.02 | 9.40 |
| 2. NAD-dependent protein deacetylase sirtuin-1 | SIRT1 | Q96EB6 | 81.68 | 4.55 |
| 3. Protein Wnt-3a | WNT3A | P56704 | 39.36 | 8.52 |
| 4. Pentraxin-related protein PTX3 | PTX3 | P26022 | 41.97 | 4.94 |
| 5. Thrombospondin-1 | THBS1 | P07996 | 129.38 | 4.71 |
| 6. Growth/differentiation factor 15 | GDF15 | Q99988 | 34.14 | 9.79 |
| 7. Cell division control protein 42 | CDC42 | P60953 | 21.25 | 6.16 |
| 8. Dihydropyrimidinase-related protein 2 | DPYSL2 | Q17555 | 62.29 | 5.95 |
| 9. Prosaposin | PSAP | P07602 | 58.11 | 5.06 |
| 10. Brain-derived neurotrophic factor | BDNF | P23560 | 27.81 | 9.01 |
| 11. Nerve growth factor | NGF | P01138 | 26.95 | 9.94 |
| 12. Fibroblast growth factor 2 | FGF2 | P09038 | 30.77 | 11.18 |
| 13. Stromal cell-derived factor 1 | CXCL12 | P48061 | 10.66 | 9.92 |
| 14. Ephrin A-2 | EFNA2 | O43921 | 23.87 | 6.99 |
| 15. Vascular endothelial growth factor | VEGFA | P15692 | 27.04 | 9.21 |
| 16. Microtubule-associated protein tau | MAPT | P10636 | 78.92 | 6.25 |
| 17. Beta-secretase 1 | BACE1 | P56817 | 55.76 | 5.31 |
| 18. Amyloid-beta A4 protein | APP | P05067 | 86.94 | 4.73 |
| 19. Prion protein | PRNP | P04156 | 27.66 | 9.13 |
| 20. CD81 | CD81 | P60033 | 25.80 | 5.09 |
| 21. Tetraspanin-6 | TSPAN6 | O43657 | 27.56 | 8.44 |
| 22. CD9 | CD9 | P21926 | 25.41 | 6.80 |
| 23. Neutral sphingomyelinase 2 | SMPD3 | Q9NY59 | 71.03 | 5.52 |
aUniProtKB Acc. Numb., UniProt Knowledgebase Accession Number. bMW, Molecular weight. CpI, Isoelectric point.