Table 1.

Cancer models of the secretory organs in which SIRT1 has been studied.

	Experimental models and specimens	References
Ovarian cancer of epithelial origin	Normal ovaries, endometriosis with/without carcinoma, OvCa (endometrioid; clear cell; mucinous; serous). OvCa cell lines. Serous EOC.	(4, 23–28)
Thyroid carcinoma	Murine thyroid cancers. Thyroid cell lines. Nude mice models. Human normal and tumor thyroid specimens	(2, 37, 38)
Pancreatic cancer	Confirmed human PC and non-tumor pancreatic specimens. PC cell lines. Normal human pancreatic ductal epithelium. PC xenografts. Human chronic pancreatitis specimens	(41–45)
Pancreatic neuroendocrine tumors	Formalin fixed paraffin-embedded human samples	(3)
Gastric cancer	Human primary GC specimens. GC cell lines. Clinical trials concerning gastrointestinal cancers, overall survival and SIRT1. NCBI GEO databases of mRNA profiles. Formalin fixed paraffin-embedded human samples	(52–56)
Hepatic cancer	Primary liver cancer organoids (hepatocellular carcinoma; cholangiocarcinoma; combined HCC/CC; healthy liver). HCC mouse xenografts. HCC cell lines and primary human tissues	(61, 63, 64)