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. 2018 Sep 24;9:2050. doi: 10.3389/fimmu.2018.02050

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Copyright © 2018 Chakraborty, Karasu and Huber-Lang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of post-trauma complement activation bridging altered cellular responses of the innate and the adaptive immune system. Trauma alters one or more cellular responses of neutrophils, monocytes, and B-cells and by directly modulating complement regulatory proteins on T-cells, apart from robust activation of complement factors. Though there is a direct effect of trauma on T-cells and B-cells, involvement of mediating complement factors are unreported. CR1, complement receptor 1; HLA-DR, human leukocyte antigen—antigen D Related; MAPK, mitogen-activated protein kinase; PAMP, pathogen-associated molecular pattern.