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. 2018 Aug 11;5(5):818–829. doi: 10.1002/ehf2.12341

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© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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In situ tissue typing of endomyocardial biopsies in parvovirus B19‐positive myocarditis patients before (mRNA+) and after telbivudine treatment (mRNA−) via imaging mass spectrometry. (A) Probabilistic latent semantic analysis could distinguish the protein signatures of the B19V mRNA+ (red) and B19V mRNA− (blue) patients (Patients 3 and 4 of Table 1). (B) Peptides from tenascin‐C (TNC; 1740 Da) show significantly lower intensities (receiver operating characteristic > 0.72; P < 0.001) in B19 mRNA− compared with B19V mRNA+ endomyocardial biopsy.