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. 2018 Aug 23;12(10):1689–1705. doi: 10.1002/1878-0261.12362

Figure 1.

Figure 1

CXCR7 is strongly expressed in ERα‐positive gynecologic cancer cells and tumor stroma. (A) A panel of uterine, ovary, and breast cancer cell lines was analyzed for CXCR7 mRNA expression by qPCR. Each expression value was quantified to RPLP0 expression. Data are representative of at least three independent experiments performed in triplicates. Error bars represent SEM. (B) Boxplots showing the expression levels of CXCR7/ACKR3 in microdissected normal and tumor epithelium with respective matched surrounding stromal sections included in the ovarian dataset GSE40595. (C) Boxplots of the expression level of CXCR7 in microdissected normal and tumor samples of GSE38666. (D) Boxplots showing the relative CXCR7 expression in the various molecular subtypes of the ovarian TCGA dataset. (E) Boxplots of the expression level of ESR1 in microdissected normal and tumor samples of GSE38666. (F) Estrogen‐regulation of CXCR7 gene expression. Cells were treated with 10 nm 17β‐estradiol (E2) or ethanol vehicle (–) for 16 h, and then harvested for CXCR7 expression as in A. Data were analyzed using Student's t‐test and are representative of at least three independent experiments performed in triplicates. Error bars represent SEM. *P < 0.001 versus respective vehicle‐treated cells.