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. 2018 Sep 3;12(10):1797–1810. doi: 10.1002/1878-0261.12374

Figure 2.

Figure 2

Type and location of tumor‐infiltrating immune cells. Tumors derived from the A375 cell line were largely immune cell‐excluding, whereas tumors derived from the MDA‐MB‐468 and MDA‐MB‐231 cell lines were highly infiltrated by CD45+, CD3+, and CD8+ cells (A–E). Although the position of immune cells within metastases was largely similar to the matched primary tumor, lung metastases derived from both A375 and MDA‐MB‐231 were significantly more densely infiltrated by CD45+ (F), CD3+ (G) and CD8+ (H) than matched primary tumors, liver metastases and recurrent tumors (*, P < 0.05 by Student's t‐test, C–E n = 4–6, F‐H n = 6–9). Black and white scale bar 250 μm and 100 μm, respectively.