Table 4.
Placental histology associated with any stage ROP and type 1 ROP
| Placental pathology | No ROP |
Any stage ROP |
Type 1 ROP |
|||
|---|---|---|---|---|---|---|
| Adjusted OR (95% CI) | p-valuea | Adjusted OR (95% CI) | p-valuea | Adjusted OR (95% CI) | p-valuea | |
| CPI | 1.008 (0.492–2.068) | .982 | 1.647 (0.702–3.992) | .246 | 2.739 (1.112–6.749) | .029* |
| ACA | 0.811 (0.429–1.940) | .811 | 1.267 (0.531–3.023) | .594 | 0.833 (0.319–2.173) | .708 |
| MVU | 0.630 (0.315–1.261) | .630 | 2.036 (0.865–4.792) | .103 | 0.570 (0.211–1.539) | .267 |
| FVTOD | 0.815 (0.298–2.226) | .690 | 1.080 (0.360–3.240) | .126 | 0.424 (0.141–1.272) | .126 |
Chronic placental inflammation was statistically associated with type 1 ROP by multiple logistic regression analysis.
ROP, retinopathy of prematurity; OR, odds ratio; CI, confidence interval; CPI, chronic placental inflammation; ACA, amniotic fluid infection/inflammation; MVU, maternal vascular underperfusion; FVTOD, fetal vascular thrombo-occlusive disease.
*
p < .05.
a
Adjusted for gestational age, birth weight, sex, duration of oxygen treatment, pre-eclampsia, IUGE and the overlapping placental pathology.