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Intratumoral fibrosis (ITF). Hematoxylin and eosin staining is compared with trichrome staining. (A, B) Grade 1 ITF mainly composed of loose connective tissue. (C, D) Grade 2 ITF composed of collagen fibers and loose connective tissue. (E, F) Grade 3 ITF mainly composed of sclerotic collagen fibers.
