Table 2.
Clinical and neuropsychological characteristics at baseline in cognitively normal subgroups*
| CNcon | CNnoncon | p-value | |
|---|---|---|---|
| N | 15 | 73 | |
| Age (SD), y | 72.87 (3.80) | 71.86 (3.72) | 0.897 |
| Education (SD), y† | 9.53 (5.03) | 9.71 (4.39) | 0.018 |
| Female, N | 5 | 26 | 0.866 |
| SMC | 3.27 (3.29) | 2.82 (2.44) | 0.547 |
| IADL | 0.03 (0.73) | 0.06 (0.12) | 0.397 |
| GDS | 7.87 (3.70) | 7.27 (5.21) | 0.677 |
| DSQ† | 3.80 (1.6) | 2.74 (1.45) | 0.013 |
| MMSE | 0.13 (0.65) | 0.35 (0.72) | 0.272 |
| Attention | |||
| DSF | 0.36 (1.23) | 0.37 (1.15) | 0.993 |
| DSB | 0.21 (1.04) | 0.08 (1.12) | 0.682 |
| Language | |||
| BNT† | 0.11 (0.75) | 0.60 (0.81) | 0.035 |
| Visuospatial functions | |||
| RCFT copy† | -0.01 (0.86) | 0.57 (0.54) | 0.001 |
| Memory | |||
| SVLT_imm | 0.28 (0.64) | 0.37 (0.85) | 0.675 |
| SVLT_delayed | 0.07 (0.69) | 0.42 (0.96) | 0.181 |
| SVLT_rec | 0.33 (0.61) | 0.56 (0.64) | 0.204 |
| RCFT_imm | 0.11 (1.09) | 0.38 (0.93) | 0.324 |
| RCFT_delayed | 0.12 (0.93) | 0.38 (0.92) | 0.322 |
| RCFT_rec | 0.59 (0.45) | 0.20 (0.76) | 0.059 |
| Executive functions | |||
| Fluency_A | 0.31 (0.88) | 0.57 (0.96) | 0.337 |
| Fluency_P | 0.23 (0.85) | 0.33 (0.96) | 0.726 |
| Stroop | 0.68 (0.65) | 0.63 (0.74) | 0.838 |
| TMT_A | 0.47 (0.48) | 0.37 (0.55) | 0.553 |
| TMT_B | 0.33 (0.63) | 0.44 (0.62) | 0.556 |
neuropsychological data presented as group mean z-scores based on age-, education-, and gender specific normative information (standard deviation),
significant group-difference.
CNcon: cognitively normal elders who converted to mild cognitive impairment or pre-mild cognitive impairment, CNnoncon: cognitively normal elders who were stable, SMC: subjective memory complaints, IADL: instrumental activities of daily living, GDS: geriatric depression scale, DSQ: dementia screening questionnaire, MMSE: mini mental status examination, DSF: digit span forward, DSB: digit span backward, BNT: Boston naming test (15 item), RCFT copy: Rey complex figure test copy score, SVLT_imm: Seoul verbal learning test, immediate recall score, SVLT_delayed: SVLT, delayed recall score, SVLT_rec: SVLT, recognition score, RCFT_imm: RCFT, immediate recall score, RCFT_delayed: RCFT, delayed recall score, RCFT_rec: RCFT, recognition score, Fluency_A: fluency score for animal, Fluency_P: fluency score for 3 Korean alphabet, Stoop: Stroop score for color naming in color-word in incongruent condition, TMT: trail making test