Figure 2. Effect of insulin receptor inhibition on the transport of radioactive insulin across the BBB following fasting.

Level of ¹²⁵I‐insulin in whole brain was measured in mice co‐injected with vehicle (n = 12, open circles) or 1 μg S961 (n = 12, filled circles), and fed mice (n = 6, open squares). Values are corrected for vascular space and expressed as the Delta B/S ratio (μl/g). Linear regression analysis was included (straight or dashed line) to depict the influx.