Table 3.
Electrophysiological properties of DG granule cells of mice with the presence of E‐4031
| Parameter | Control | E‐4031 |
|---|---|---|
| Action potential threshold (mV) | −49.9 ± 0.5 (n = 9) | −51.8 ± 1.0 (n = 9)* |
| Amplitude (mV) | 115.9 ± 2.3 (n = 9) | 111.2 ± 2.3 (n = 9) |
| Input resistance (MΩ) | 221.0 ± 13 (n = 9) | 265.7 ± 13 (n = 9)** |
| Delay to action potential (ms) | 12.7 ± 0.7 (n = 9) | 11.2 ± 0.4 (n = 9)* |
| First action potential fast AHP (mV) | −9.7 ± 0.7 (n = 9) | −6.4 ± 1.2 (n = 9)** |
| Second action potential fast AHP (mV) | −13.0 ± 1.2 (n = 9) | −11.0 ± 1.4 (n = 9)* |
| Third action potential fast AHP (mV) | −11.9 ± 1.1 (n = 9) | −11.8 ± 1.5 (n = 9) |
| Forth action potential fast AHP (mV) | −11.4 ± 1.3 (n = 9) | −10.9 ± 1.4 (n = 9) |
| Resting membrane potential (mV) | −80.2 ± 0.15 (n = 7) | −80.0 ± 0.04 (n = 7) |
| Half‐width of action potential (ms) | 1.67 ± 0.07 (n = 9) | 1.73 ± 0.08 (n = 9) |
| Membrane time constant (ms) | 17.3 ± 0.7 (n = 5) | 17.1 ± 1.1 (n = 5) |
Data are reported as means ± SEM for DG granule cells of mice. * P < 0.05, ** P < 0.01, Student's t test.