Table 9.

The diagnosis of acute kidney injury using serum creatinine levels in the RIFLE, AKIN, KDIGO, and ICA-AKI criteria

	RIFLE [283]	AKIN [286]	KDIGO [289]	ICA-AKI [282]
Definition	Increase in sCr to ≥1.5 times baseline within 7 days	Increase in sCr by ≥0.3 mg/dL within 48 hours or increase in sCr ≥1.5 times baseline within 48 hours	Increase in sCr by ≥0.3 mg/dL within 48 hours or increase in sCr ≥1.5 times baseline within 7 days	Increase in sCr by ≥0.3 mg/dL within 48 hours or increase in sCr ≥1.5 times baseline within 7 days
Staging
Stage 1	(Risk) sCr increase 1.5-1.9 times baseline	sCr increase 1.5-1.9 times baseline or sCr increase ≥0.3 mg/dL	sCr increase 1.5-1.9 times baseline or sCr increase ≥0.3 mg/dL	sCr increase ≥0.3 mg/dL or sCr increase 1.5-2 times baseline
Stage 2	(Injury) sCr increase 2.0-2.9 times baseline	sCr increase 2.0-2.9 times baseline	sCr increase 2.0-2.9 times baseline	sCr increase >2 and ≤3 times baseline
Stage 3	(Failure) sCr increase ≥3 times baseline or sCr increase ≥4.0 mg/dL with an acute increase of at least 0.5 mg/dL	sCr increase ≥3 times baseline or sCr increase ≥4.0 mg/dL with an acute increase of at least 0.5 mg/dL	sCr increase ≥3 times baseline or sCr increase ≥4.0 mg/dL	sCr increase >3 times baseline or sCr increase ≥4.0 mg/dL with an acute increase ≥0.3 mg/dL or initiation of renal replacement therapy

RIFLE, Risk, Injury, Failure, Loss of renal function, and End-stage renal disease; AKIN, Acute Kidney Injury Network; KDIGO, Kidney Disease Improving Global Outcomes; ICA-AKI, International Club of Ascites-Acute Kidney Injury; sCr, serum creatinine.