Figure EV3. No polySer aggregates in unaffected white matter regions of SCA8 BAC mouse cerebellum and SCA8 human autopsy brains.

1. White matter integrity visualized by luxol fast blue (LFB) staining (right) and polySer aggregates detected by α‐SerCT antibody (left).
2. White matter integrity visualized by luxol fast blue (LFB) staining (right) and polySer aggregates detected by α‐SerCT2 antibody (left) in control (top) and SCA8 (bottom and enlarged panel) human autopsy tissue.