Table 1.
Summary of polySer staining in SCA8 and control autopsy tissue
| Case | Age | Sex | SCA8 Repeat | PMI | Cerebellum | Brainstem | Frontal Cortex | |
|---|---|---|---|---|---|---|---|---|
| SCA8 | 1 | 80 | F | 104 | 28 | +++ | ++ | + |
| 2 | 74 | F | 109 | 11.5 | +++ | + | + | |
| 3 | 85 | F | 91 | 8 | ++ | + | n.d | |
| 4 | 76 | M | 197 | 4.5 | + | n.d | + | |
| 5 | 83 | M | 7 | +++ | ++ | − | ||
| 6 | 59 | F | 790 | +++ | n.d | + | ||
| 7 | 60 | F | 105 | 10 | +++ | n.d | n.d | |
| CTRL | 1 | n.d | n.d | − | ||||
| 2 | n.d | n.d | − | |||||
| 3 | 40 | M | 6 | − | − | − | ||
| 4 | 45 | F | 20 | − | − | n.d | ||
| HD | 1 | 46 | F | 7 | − | − | ||
| HDL2 | 1 | 41 | F | 3 | − | − | − | |
| SCA2 | 1 | 56 | F | 3.5 | − | n.d | n.d | |
| SCA5 | 1 | M | − | − | n.d | |||
| SCA7 | 1 | 59 | F | 22 | − | n.d | n.d | |
| DM1 | 1 | 68 | F | − | − | − |
RAN staining: −, negative; +, low‐intensity staining; ++, moderate intensity; +++, frequent and intense; ++++, highly frequent positive cells with high‐intensity staining. SCA8, spinocerebellar ataxia type 8; CTRL, control; HD, Huntington disease; HDL2, Huntington disease like‐2; SCA2, spinocerebellar ataxia type 2; SCA5, spinocerebellar ataxia type 5; SCA7, spinocerebellar ataxia type 7; DM1, myotonic dystrophy type 1; n.d, not determined; M, male; F, female; PMI, post‐mortem interval.