Table 4. Hormone changes over time by nutritional group

Hormones	MAM Geometric mean ratio (95% CI)			SAM Geometric mean ratio (95% CI)			pb
	Days 14 vs. 0	Days 28 vs. 0	pa	Days 14 vs. 0	Days 28 vs. 0	pa
Leptin, ng/ml	1.6 (1.1, 2.4)	1.1 (0.8, 1.6)	0.002	1.8 (1.3, 2.6)	1.6 (1.1, 2.3)	<0.001	0.18
sOBR, ng/ml	0.88 (0.8, 0.9)	1.0 (0.9, 1.1)	0.02	0.8 (0.7, 0.9)	0.8 (0.7, 0.9)	<0.001	0.02
Molar excess sOBR/leptin	0.5 (0.4, 0.8)	0.8 (0.6, 1.3)	<0.001	0.5 (0.3, 0.7)	0.5 (0.3, 0.7)	<0.001	0.04
Total ghrelin, ng/ml	0.9 (0.7, 1.1)	0.8 (0.6, 0.9)	0.007	0.7 (0.6, 0.9)	0.7 (0.6, 0.9)	<0.001	0.11
IGF-1, ng/ml	1.6 (1.3, 2.1)	1.3 (1.0, 1.7)	<0.001	2.1 (1.7, 2.8)	2.2 (1.7, 2.8)	<0.001	0.001
IGFBP3, ng/ml	1.3 (1.1, 1.5)	1.1 (1.0, 1.3)	0.002	1.7 (1.5, 2.0)	1.5 (1.3, 1.7)	<0.001	<0.001
Molar ratio IGF1:IGFBP3	1.3 (1.1, 1.6)	1.1 (1.0, 1.5)	0.005	1.2 (1.0, 1.5)	1.5 (1.2, 1.8)	<0.001	0.02
C-peptide, pM/l	1.1 (0.7, 1.8)	1.2 (0.7, 2.0)	0.69	0.9 (0.5, 1.5)	0.9 (0.6, 1.6)	0.91	0.70
Insulin, µIU/ml	0.8 (0.3, 2.1)	1.4 (0.5, 3.5)	0.40	1.9 (0.8, 4.7)	1.6 (0.7, 4.0)	0.16	0.23
Cortisol, µ/dl	0.9 (0.6, 1.3)	0.9 (0.6, 1.3)	0.64	0.7 (0.5, 1.0)	0.8 (0.6, 1.1)	0.03	0.47

^aBonferroni’s-adjusted test assessing differences over time.

^bWald test assessing interaction between nutritional group and time.