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. 2018 Oct 1;6:102. doi: 10.1186/s40478-018-0605-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Selected electron micrographs of human brain biopsies from iNPH patients. a Interaction of mitochondria with plasma membrane (PM), nucleus (n), Golgi and lisosomes (L) (from left to right). b Interactions between ER and mitochondria (m). Small stretches of ER in contact with mitochondria (top left and right), longer contacts of ER in contact with mitochondria (bottom panel, left and middle), and a point contact (bottom, right). c MERCS in pre-synaptic (left) and post-synaptic (right) density. Black arrow head – mitochondria-PM interaction, black arrow – mitochondria-nucleus interaction, # – mitochondria-lysosome interaction, white arrow – ER, white arrow head – MERCS, * - synapse. Scale bar = 500 nm