Fig. 3.

Examples of selection for double-dose artemisinin resistance. Demonstrative parasitemia trends as seen at different time points during the resistance selection process are shown from mice that received a 2-day regimen comprising two doses 24 h apart of (a) 9.6 mg/kg, (b) 38.4 mg/kg, or (c) 80 mg/kg artesunate (i.e., total of 19.2 mg/kg, 86.8 mg/kg, or 160 mg/kg AS per APC). Arrows indicate day of intravenous drug delivery. Results were reproduced in several mice as indicated in Table S2B