Table 4.
Primary outcomes in the ACEI/ARB and CCB groups after propensity score matching.
| Outcome | ACEI/ARB (n = 4445) |
CCB (n = 4445) |
ACEI/ARB versus
CCB |
|
|---|---|---|---|---|
| HR (95% CI)† | p | |||
| 2-year follow up | ||||
| All-cause mortality | 347 (7.8) | 344 (7.7) | 1.01 (0.87, 1.17) | 0.940 |
| Any stroke# | 316 (7.1) | 295 (6.6) | 1.07 (0.91, 1.26) | 0.397 |
| Hemorrhagic stroke | 150 (3.4) | 134 (3.0) | 1.12 (0.89, 1.41) | 0.343 |
| Ischemic stroke | 186 (4.2) | 185 (4.2) | 1.002 (0.82, 1.23) | 0.987 |
| Primary composite end-point§ | 603 (13.6) | 579 (13.0) | 1.04 (0.93, 1.17) | 0.480 |
| 5-year follow up | ||||
| All-cause mortality | 726 (16.3) | 715 (16.1) | 1.01 (0.91, 1.12) | 0.818 |
| Any stroke# | 621 (14.0) | 595 (13.4) | 1.04 (0.93, 1.17) | 0.463 |
| Hemorrhagic stroke | 297 (6.7) | 276 (6.2) | 1.08 (0.91, 1.27) | 0.383 |
| Ischemic stroke | 382 (8.6) | 398 (9.0) | 0.95 (0.83, 1.10) | 0.508 |
| Primary composite end-point§ | 1179 (26.5) | 1145 (25.8) | 1.03 (0.95, 1.12) | 0.485 |
| At the last follow up | ||||
| All-cause mortality | 1015 (22.8) | 982 (22.1) | 1.05 (0.96, 1.15) | 0.265 |
| Any stroke# | 802 (18.0) | 803 (18.1) | 1.01 (0.92, 1.12) | 0.777 |
| Hemorrhagic stroke | 390 (8.8) | 358 (8.1) | 1.11 (0.96, 1.28) | 0.160 |
| Ischemic stroke | 502 (11.3) | 555 (12.5) | 0.91 (0.81, 1.03) | 0.140 |
| Primary composite end-point§ | 1533 (34.5) | 1518 (34.2) | 1.03 (0.96, 1.10) | 0.484 |
ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; CCB, calcium channel blocker; CI, confidence interval; HR, hazard ratio.
§
Any one of all-cause mortality, hemorrhagic stroke, and ischemic stroke.
#
Either one of hemorrhagic or ischemic stroke.
†
Propensity score was additionally treated as a covariate in the model.