Figure 2.

Myokines involved in induced-exercise muscle-adipose tissue crosstalk. The secretion and action of different types of Myokines is exercise type-dependent. Some Myokines like Irisin, Myostatin, IL-6 e IL-15 have been the subject of a number of published studies about their mechanisms. However, FGF21, Myonectin, ANGPTL4, and BAIBA need more studies about their role as exercise factor. Solid lines represent already known mechanisms, while broken lines represent the mechanisms that still have to be unraveled. The red line represents factors released during endurance training practice while the blue line represents factors released during resistance training practice. The Myokines released by exercise and their effects on White Adipose Tissue. Muscle contraction-induces a set of molecules that have an endocrine function. Muscle-adipose tissue crosstalk exerts functions such as reduction of adiposity, increase in thermogenesis due to increased adrenergic activity, increased markers of the browning phenomenon and increased lipolytic activity.