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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2018 Jan 31;1860(5):1179–1186. doi: 10.1016/j.bbamem.2018.01.020

Fig. 8.

Fig. 8

Effects of D-leucine application on L-leucine uptake. A) 0.1mM [3H]-L-leucine uptake induced by KAAT1 WT and the T67Y mutant was measured in the absence or in the presence of 4 mM unlabeled D-leucine. Data are means ± S.E. of three independent experiments with n ranging from 30 to 40 and are expressed as percentage of control uptake. (**) Statistically significant, P<0.001 when compared with WT. B) Transport current in the presence of D- and L- leucine reported as raw mean values ± SEM for WT (n = 25) and for T67Y (n = 7). The currents recorded in the presence of D-leucine are larger than the currents recorded in L-leucine for the wild type, while the opposite is true for the T67Y mutant. The inset is an enlargement of the data for T67Y (*0.05 level one-way ANOVA).