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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Int J Tuberc Lung Dis. 2018 Aug 1;22(8):937–944. doi: 10.5588/ijtld.17.0515

Table 3.

Pharmacokinetic prediction of a single intramuscular injection of anti-TB agents at an optimal release rate of 0.0015 h−1 using a qualified PBPK model.

Drug Dose Cmax Ctrough AUC Target concentration
Bedaquiline 2000 0.39 ± 0.08 0.16 ± 0.03 177 ± 36 1.6 (ECOFF) 18
Delamanid 1500 0.11 ± 0.03 0.044 ± 0.011 50 ± 12 0.04 (ECOFF) 18
Isoniazid 2000 0.39 ± 0.13 0.15 ± 0.05 170 ± 56 0.125 (CC) 19
Rifapentine 250 0.50 ± 0.06 0.21 ± 0.02 232 ± 21 0.18 (MIC*3) 20

PBPK – physiologically-based pharmacokinetic, dose is represented in mg, Cmax – maximum plasma concentration, Ctrough – trough plasma concentration 4 weeks after administration, AUC – area under the plasma concentration curve. Cmax, Ctrough and target concentration are expressed as mg/L, AUC is expressed as mg.h/L; ECOFF – epidemiological cut-off, CC – critical concentration, MIC – minimum inhibitory concentration