Table 1.

Other relevant factors on endothelial injury in the literature

References	Relevant risk factors	Main viewpoint
Jing et al. 2015[65]	SM22alpha promoter	In VSMC, the SM22alpha promoter, carried by a recombinant lentiviral vector, was used to successfully infect and selectively upregulate expression of p27 protein, which restrains intimal hyperplasia with inhibition of endothelial repair
Wang et al. 2015[66]	SOCE	The decrease of SOCE led to EPC damage potentially by downregulating SOCC and impairing eNOS pathway
Ostrowski et al. 2017[67]	Sympathoadrenal activation	Sympathoadrenal activation, injuring endothelial function, was dramatically correlative with hypocoagulability and endotheliopathy
Rodríguez-Carrio et al. 2015[68]	RDW	RDW was related with endothelial progenitor cells consumption and incremental concentrations of various intermediaries connected to endothelial injury, thereby which unmask novel insight on the science of RDW as predictive factors
Bochenek et al. 2016[69]	Aging	The damaged proliferation and migration of local endothelial cells as well as exhaustion of endogenous endothelial repair mechanisms become worse with age by impairing re-endothelialization
Reynolds et al. 2016[70]	Deficiency of Vitamin D	Vitamin D shortage is associated with poor vascular repair and weakened endothelial function and may regulate inflammatory reaction

VSMC: Vascular smooth muscle cells; EPC: Endothelial progenitor cell; SOCE: Store-operated calcium entry; SOCC: Store-operated calcium channel; eNOS: Endothelial nitric oxide synthase; RDW: Red cell distribution width.