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Overview of the conceptual framework of this experimental study. Assays are shown in green and inhibitors are in red with the dotted lines indicating sites of inhibition. UTP inhibits pore formation by a mechanism involving P2Y4 receptors and phospholipase [5]. Low [Ca2+]o was solution A without added calcium. NAC is the antioxidant, n-acetyl-cysteine. Although not the focus of this study, capillary vasoconstriction occurs with P2X7 activation [1,26].
