Figure 4. Core pathways involved in glioblastoma multiforme.
RTK–PI3K–AKT–mTOR and RTK–RAS–RAF–MEK–ERK signaling pathways and putative inhibitors.
BBB: Blood–brain barrier; EGFR: EGF receptor; GBM: Glioblastoma multiforme; PDGFR: PDGF receptor.
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