Table 1. . Classic classification of glioblastoma multiforme.
| Subtype | Incidence (%) | Origin | Alterations (%) | Clinical history | Median overall survival (months)† |
|---|---|---|---|---|---|
| Primary or de novo GBM | 95% | No recognizable precursor lesions |
LOH 10q (70) EGFR amplification (36) P16INK4a deletion (31) TP53 mutation (28) PTEN mutation (25) |
<3 months (68%) <6 months (84%) |
4.7 |
| Secondary GBM | 5% | Developed from diffuse astrocytoma or anaplastic astrocytoma |
LOH 10q (63) EGFR amplification (8) P16INK4a deletion (19) TP53 mutation (65) PTEN mutation (4) |
Low-grade astrocytoma origin: 5.1 years; anaplastic astrocytoma: 1.9 years | 7.8 |
The classic classification includes primary and secondary GBM.
†Median overall survival without treatment.
GBM: Glioblastoma multiforme.