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. 2018 Apr 29;89(10):1016–1023. doi: 10.1136/jnnp-2017-317887

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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Change in metabolic index relative to motor neuron involvement, sites of onset, clinical staging and genotype. Box plots summarising the change in metabolic index relative to (A) lower and (B) upper motor neuron scores, (C) site of onset, (D) King’s staging and (E-F) genotype (from table 1). Motor neuron scores were determined using a modified Ravits Scale. Binning reflects increasing upper or lower motor neuron involvement. P values indicate the significance of change in metabolic index relative to increasing scores, as determined by analysis of variance (ANOVA). Dots represent outliers (Tukey post hoc test). LMN, lower motor neuron; UMN, upper motor neuron; AA, UNC13A A/A genotype; AC, UNC13A A/C genotype; CC, UNC13A C/C genotype.