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. 2018 Apr 29;89(10):1016–1023. doi: 10.1136/jnnp-2017-317887

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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Change in weight, body mass index, fat mass (%), fat-free mass (kg), ALSFRS-R and FVC in hypermetabolic and normometabolic ALS participants. Relationship between time since metabolic assessment and measures of (A) body weight, (B-D) anthropometric indices and (E-F) clinical parameters of disease in normometabolic (blue line) and hypermetabolic (red line) patients with ALS. Hypermetabolism is negatively correlated with ALSFRS-R (p=0.01; −0.39 points/month for normometabolic patients with ALS vs −0.68 points/month for hypermetabolic patients with ALS). ALS, amyotrophic lateral sclerosis; ALSFRS-R, Revised ALS Functional Rating Scale; BMI, body mass index; FVC, forced vital capacity.