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. 2018 Sep 24;5:263. doi: 10.3389/fmed.2018.00263

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Copyright © 2018 Soares, Fachin, Trombone, Rosa, Ghidella and Belone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological and bacilloscopic characteristics of lesions of lepromatous side in activity, lepromatous side in regression, and R2 lesions. Active lesions with vacuolated macrophages containing a large number of solid bacilli (A–D). Lesions in regression showing multivacuoled macrophages containing a large number of multifragmented bacilli (F–I). R2 lesions, the macrophages display characteristics similar to those seen in lesions in regression undergoing an influx of neutrophils (K–N). Expression of AKR1B10 in the same samples. Negative expression in samples of lepromatous side in activity (E). Positive expression (marked by →) in samples of lepromatous side lesions in regression (J), and R2 lesions (O). Hematoxylin-eosin staining (A–C, F–H, K–M). Fite-Faraco staining for bacilloscopy (D,I,N).