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. 2018 Sep 24;5:263. doi: 10.3389/fmed.2018.00263

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Copyright © 2018 Soares, Fachin, Trombone, Rosa, Ghidella and Belone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of AKR1B10 in different components of skin and granulomas in the samples. Absence (marked with a^*) of AKR1B10 expression in most components of skin and in some granulomas (A–C). Positive expression (marked with a →) in granulomas present in other areas of the same sample (A,D). Moderate or strong expression of marker almost exclusively in the cytoplasm of macrophages present in lesions of lepromatous lesions in regression (E) and R2 (F) showing staining of intracytoplasmatic vacuoles/lysosomes (F).