Skip to main content
. 2018 Aug 6;293(39):15055–15069. doi: 10.1074/jbc.RA117.000633

Figure 7.

Figure 7.

Mice in which CD47, CD36, and/or CD36 and CD47 (DKO) are genetically deleted have altered spinal trabecular bone mass and microarchitecture. Mean bone density was determined by micro-CT in 12-week-old female CD47−/−, CD36−/−, and DKO mice and 12-week-old female WT controls. The data represent the trabecular envelope of the spine. In CD47−/− mice, there was no significant effect on trabecular bone mass, but trabecular number was significantly increased, and trabecular spacing was reduced (n = 10 for WT and n = 5 for CD47−/− mice; **, p ≤ 0.01; NS, nonsignificant). CD36−/− mice had a significantly increased trabecular bone mass. In addition, trabecular thickness was increased, although, somewhat surprisingly, trabecular number was reduced, and trabecular spacing was increased (n = 10 for WT and n = 6 for CD36−/−; **, p < 0.01; NS, nonsignificant). Trabecular number was significantly higher, and trabecular spacing was significantly lower in the DKO animals (n = 10 for WT and n = 8 for DKO; **, p < 0.005; NS, nonsignificant). The scatter plots represent mean ± S.D. (error bars).