Figure 8.

Mice in which CD47, CD36, or both CD36 and CD47 (DKO) are genetically deleted have altered femoral cortical bone mass or cortical parameters. Mean bone density was determined by micro-CT in 12-week-old female CD47^−/−, CD36^−/−, and DKO mice and 12-week-old female WT controls. In CD47^−/− mice, cortical bone volume and cortical thickness were both significantly reduced (n = 10 for WT and n = 5 for CD47^−/− mice; **, p ≤ 0.01; ***, p < 0.0001; NS, nonsignificant). Cortical bone mass was significantly increased in the CD36^−/− mice (n = 10 for WT and n = 11 for CD36^−/−; **, p < 0.01; NS, nonsignificant). Cortical thickness was significantly reduced, and endosteal circumference was significantly increased in the DKO mice. Because periosteal circumference did not change but endosteal circumference increased, per force cortical thickness was reduced (n = 10 for WT and n = 8 for DKO; *, p < 0.05; **, p < 0.005; NS, nonsignificant). The scatter plots represent mean ± S.D. (error bars).