Figure 8.

Retinal photodamage in Cntf^−/− mice. A, light microscopic images of WT and Cntf^−/− superior retinas before photodamage. Scale bar denotes 20 μm. B, light microscopy showing severe retinal degeneration in Cntf^−/−, but not WT, mice kept in darkness for 5 days after exposing to 12,000 lux light for 75 min. C, higher magnification images of the superior retinas of WT and Cntf^−/− mice exposed to the intense light. D, thickness of the retinal outer nuclear layers in WT and Cntf^−/− mice in B. Numbers on the x-axis indicate distance from optic nerve head. Error bars show S.D. (n = 4).