Table 1.
Baseline characteristics
| Parameter | FEV1/FVC <0.70 (n=63) |
FEV1/FVC ≥0.70 (n=196) |
Difference | 95% CI |
|---|---|---|---|---|
| Recipient data | ||||
| Age in years, mean ± SD | 53.6±8.4 | 51.2±10.9 | 2.4 years | −0.3, 5.1 years |
| Age (>60.0 years), n (%) | 11 (17.5%) | 42 (21.4%) | 3.9% | −7.1%, 14.9% |
| Male sex, n (%) | 49 (77.8%) | 146 (74.5%) | 3.3% | −8.6%, 15.2% |
| Body mass index (kg/m2), mean ± SD | 26.7±4.6 | 24.6±3.9 | 2.1 kg/m2 | 0.9, 3.3 kg/m2 |
| Body mass index (>25.0 kg/m2), n (%) | 39 (61.9%) | 78 (39.8%) | 22.1% | 8.3%, 35.9% |
| Coronary artery disease, n (%) | 38 (60.3%) | 75 (38.3%) | 22.0% | 8.2%, 35.8% |
| Arterial hypertension, n (%) | 41 (65.1%) | 103 (52.6%) | 12.5% | −1.2%, 26.2% |
| Dyslipidemia, n (%) | 48 (76.2%) | 114 (58.2%) | 18.0% | 5.4%, 30.6% |
| Diabetes mellitus, n (%) | 22 (34.9%) | 61 (31.1%) | 3.8% | −9.6%, 17.2% |
| Renal insufficiency*, n (%) | 39 (61.9%) | 102 (52.0%) | 9.9% | −4.0%, 23.8% |
| Glomerular filtration rate (ml/min/1.73 m2), mean ± SD | 55.3±20.0 | 59.6±23.3 | 4.3 mL/min/1.73 m2 | −1.7, 10.3 mL/min/1.73 m2 |
| History of smoking, n (%) | 60 (95.2%) | 86 (43.9%) | 51.3% | 42.6%, 60.0% |
| Previous open-heart surgery | ||||
| Overall open-heart surgery, n (%) | 17 (27.0%) | 54 (27.6%) | 0.6% | −12.0%, 13.2% |
| CABG surgery, n (%) | 8 (12.7%) | 28 (14.3%) | 1.6% | −8.0%, 11.2% |
| Congenital, valvular or, ventricular surgery, n (%) | 10 (15.9%) | 19 (9.7%) | 6.2% | −3.7%, 16.1% |
| VAD surgery, n (%) | 1 (1.6%) | 9 (4.6%) | 3.0% | −1.3%, 7.3% |
| Principal diagnosis for HTX | ||||
| Ischemic CMP, n (%) | 32 (50.8%) | 61 (31.1%) | 19.7% | 5.7%, 33.7% |
| Nonischemic CMP, n (%) | 21 (33.3%) | 101 (51.5%) | 18.2% | 4.6%, 31.8% |
| Valvular heart disease, n (%) | 3 (4.8%) | 6 (3.1%) | 1.7% | −4.1%, 7.5% |
| Cardiac amyloidosis, n (%) | 7 (11.1%) | 28 (14.3%) | 3.2% | −6.0%, 12.4% |
| Donor data | ||||
| Age in years, mean ± SD | 46.9±12.0 | 44.1±12.3 | 2.8 years | −0.7, 6.3 years |
| Male sex, n (%) | 24 (38.1%) | 56 (28.6%) | 9.5% | −4.0%, 23.0% |
| Body mass index, mean ± SD | 24.5±4.2 | 25.0±4.8 | 0.5 kg/m2 | −0.7, 1.7 kg/m2 |
| Transplant sex mismatch | ||||
| Mismatch, n (%) | 27 (42.9%) | 102 (52.0%) | 9.1% | −5.0%, 23.2% |
| Donor (m) to recipient (f), n (%) | 1 (1.6%) | 6 (3.1%) | 1.5% | −2.4%, 5.4% |
| Donor (f) to recipient (m), n (%) | 26 (41.3%) | 96 (48.9%) | 7.6% | −6.4%, 21.6% |
| Perioperative data | ||||
| Ischemic time (min), mean ± SD | 257.6±57.5 | 245.8±55.3 | 11.8 minutes | −4.7, 28.3 minutes |
| Ischemic time (≥240 minutes), n (%) | 39 (61.9%) | 111 (56.6%) | 5.3% | −8.5%, 19.1% |
| Biatrial HTX, n (%) | 1 (1.6%) | 1 (0.5%) | 1.1% | −2.2%, 4.4% |
| Bicaval HTX, n (%) | 23 (36.5%) | 62 (31.6%) | 4.9% | −8.6%, 18.4% |
| Total orthotopic HTX, n (%) | 39 (61.9%) | 133 (67.9%) | 6.0% | −7.7%, 19.7% |
Note:
*
Glomerular filtration rate <60 mL/min/1.73 m2.
Abbreviations: CABG, coronary artery bypass graft; CMP, cardiomyopathy; f, female; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEV1/FCV, Tiffeneau index; HTX, heart transplantation; m, male; VAD, ventricular assist device.