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. 2018 Sep 27;11:2095–2106. doi: 10.2147/JPR.S144852

Figure 1.

Figure 1

(A) Skin/muscle incision and retraction (SMIR)-induced thermal response to pain. Compared with the control group, #P < 0.05; compared with the Sham group, *P < 0.05, **P < 0.01. (B) SMIR-induced allodynia (mechanical pain sensitization) in response to hind paw mechanical stimulation. The mechanical withdrawal thresholds (MWTs) in the control (naïve), sham, and SMIR groups are plotted at baseline and at different time points after SMIR. The decreased MWT after SMIR is indicative of allodynia. Compared with the control (naïve) group, #P < 0.05, ##P < 0.01, ###P < 0.001; compared with the Sham group, *P < 0.05, ***P < 0.001.