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Inhibition of WDR12 suppresses Akt-mTOR-S6K1 signaling in HCC cells.
Notes: (A) HepG2 or Huh-7 cells were infected with scrambled or WDR12 shRNAs for 72 hours, followed by analysis of Akt, mTOR, and S6K1 phosphorylation by Western blot. (B) HepG2 cells were infected with scrambled or WDR12 shRNA, one for the indicated time, followed by analysis of Akt, mTOR, and S6K1 phosphorylation by Western blot.
Abbreviations: HCC, hepatocellular carcinoma; WDR, WD-repeat protein.
