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. Author manuscript; available in PMC: 2019 Mar 12.
Published in final edited form as: Nature. 2018 Sep 12;561(7724):492–497. doi: 10.1038/s41586-018-0535-y

Extended Data Figure 10. Class B GPCRs display similar active state conformations.

Extended Data Figure 10

A-B; Alignment of the CGRP-CLR-RAMP1, sCT-CTR, ExP5-GLP-1R and GLP-1-GLP1R structures (aligned on the TM domains). Regions of divergence between CLR/CTR and GLP-1R are circled. In A, RAMP1 has been omitted for clarity. C; Position of the Gαs-Ras domain in the CTR (left), GLP-1R (GLP-1 bound; middle) and GLP-1R (ExP5 bound; right). The receptor TMs were aligned. Only the CLR (blue) and RAMP1 (orange) are displayed for clarity. D; The Gαs-Ras domain from each of the four structures, aligned according to the Gαs-Ras.